Pathology of Lethal and Sublethal Doses of Aerosolized Ricin in Rhesus Macaques
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چکیده
منابع مشابه
Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.
Ricin toxin (RT) is the second most lethal toxin known; it has been designated by the CDC as a select agent. RT is made by the castor bean plant; an estimated 50,000 tons of RT are produced annually as a by-product of castor oil. RT has two subunits, a ribotoxic A chain (RTA) and galactose-binding B chain (RTB). RT binds to all mammalian cells and once internalized, a single RTA catalytically i...
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Tench, Tinca tinca, were exposed to three treatments (one acute lethal 96 hrs Lc50/48 hrs and two chronic sublethal 10 and 25% Lc50/504 hrs) each of Mercury, Cadmium and Lead and its behaviour as an indicator of impaired hematology was studied. It was observed that impairments in hematological parameters (increased/decreased Hct, Hb, RBC, WBC and Lct) were reflected in behaviour of fish in the ...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2013
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623313492248